Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease
Identifieur interne : 000380 ( Main/Exploration ); précédent : 000379; suivant : 000381Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease
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Abstract
Thirty-three patients suspected of suffering from inflammatory bowel disease were studied. Autologous leucocytes were labelled with indium 111 oxine and re-injected simultaneously with 0.3–0.5 mg of technetium 99m granulocyte-specific monoclonal antibody BW 250/183. Two scans were obtained, the early scan 3–4 h postinjection (p.i.) and the late scan 18–24 h p.i. Using the endoscopy study as standard, the diagnostic accuracy of both agents was determined. Sensitivity, specificity and accuracy of 111In scans was 88.8%, 100.0% and 93.7% at 4 h and 94.7%, 100.0% and 96.9% at 24 h, respectively. Concerning the results using antibodies, the values were 61.1%, 100.0% and 78.1% at 4 h and 78.9%, 92.8% and 84.8% at 24 h, respectively. Segmental analysis showed concordance in 89.3% and 93.3% of the cases at 4 and 24 h, respectively. Though less sensitive and less accurate than scanning employing indium 111 leucocytes, BW 250/183 granulocyte-specific scintigraphy can be used for inflammatory bowel disease diagnosis and localization.
DOI: 10.1007/BF00173429
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Roca</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>C. Baliellas</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>L. Vilar</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>Y. Ricart</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>J. Moral</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>R. Puchal</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author><author><name>J. Martin-Comin</name><affiliation wicri:level="1"><mods:affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona</wicri:regionArea><wicri:noRegion>Barcelona</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1991_Article_BF00173429.pdf</idno><date when="1991">1991</date><idno type="doi">10.1007/BF00173429</idno><idno type="wicri:Area/Main/Corpus">000440</idno><idno type="wicri:Area/Main/Curation">000440</idno><idno type="wicri:Area/Main/Exploration">000380</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Granulocyte-specific monoclonal antibody</term><term>Inflammatory bowel disease</term><term>Leucocyte scintigraphy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Thirty-three patients suspected of suffering from inflammatory bowel disease were studied. Autologous leucocytes were labelled with indium 111 oxine and re-injected simultaneously with 0.3–0.5 mg of technetium 99m granulocyte-specific monoclonal antibody BW 250/183. Two scans were obtained, the early scan 3–4 h postinjection (p.i.) and the late scan 18–24 h p.i. Using the endoscopy study as standard, the diagnostic accuracy of both agents was determined. Sensitivity, specificity and accuracy of 111In scans was 88.8%, 100.0% and 93.7% at 4 h and 94.7%, 100.0% and 96.9% at 24 h, respectively. Concerning the results using antibodies, the values were 61.1%, 100.0% and 78.1% at 4 h and 78.9%, 92.8% and 84.8% at 24 h, respectively. Segmental analysis showed concordance in 89.3% and 93.3% of the cases at 4 and 24 h, respectively. Though less sensitive and less accurate than scanning employing indium 111 leucocytes, BW 250/183 granulocyte-specific scintigraphy can be used for inflammatory bowel disease diagnosis and localization.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="4c99b9dca742250c7988ecf4bf55b9eca4252f45"><titleInfo lang="eng"><title>Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Segarra</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Roca</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Baliellas</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Vilar</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Gastroenterologia, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ricart</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Moral</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Puchal</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Martin-Comin</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Serveis de Medicina Nuclear, Hospital de Bellvitage, Feixa Llarga s/n, 08907 Hospitalet de LL, Barcelona, Spain</affiliation></name><typeOfResource>text</typeOfResource><genre>Original articles</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1991-01-21</dateCreated><dateValid encoding="w3cdtf">2004-07-03</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">Thirty-three patients suspected of suffering from inflammatory bowel disease were studied. Autologous leucocytes were labelled with indium 111 oxine and re-injected simultaneously with 0.3–0.5 mg of technetium 99m granulocyte-specific monoclonal antibody BW 250/183. Two scans were obtained, the early scan 3–4 h postinjection (p.i.) and the late scan 18–24 h p.i. Using the endoscopy study as standard, the diagnostic accuracy of both agents was determined. Sensitivity, specificity and accuracy of 111In scans was 88.8%, 100.0% and 93.7% at 4 h and 94.7%, 100.0% and 96.9% at 24 h, respectively. Concerning the results using antibodies, the values were 61.1%, 100.0% and 78.1% at 4 h and 78.9%, 92.8% and 84.8% at 24 h, respectively. Segmental analysis showed concordance in 89.3% and 93.3% of the cases at 4 and 24 h, respectively. Though less sensitive and less accurate than scanning employing indium 111 leucocytes, BW 250/183 granulocyte-specific scintigraphy can be used for inflammatory bowel disease diagnosis and localization.</abstract><subject lang="eng"><genre>Key words</genre><topic>Inflammatory bowel disease</topic><topic>Leucocyte scintigraphy</topic><topic>Granulocyte-specific monoclonal antibody</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1991</partNumber><partNumber>Volume: 18</partNumber><partNumber>Number: 9</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1991-09-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 14</identifier><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00173429</identifier><identifier type="matrixNumber">Art2</identifier><identifier type="local">BF00173429</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>715</start><end>719</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin><recordIdentifier>259_1991_Article_BF00173429.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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